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Post-Doctoral Researcher Position in Cellular Pharmacology

Université de Sherbrooke

Sherbrooke

Temps plein

Permanent

Santé

A postdoctoral researcher position is available immediately to study the unconventional roles of a Gαs in intracellular signaling and trafficking

DESCRIPTION:

Gαs, a subunit of heterotrimeric G proteins, has a well-established role in G-protein coupled receptors (GPCRs) signaling which are the major drug targets. Although mainly known as located at the plasma membrane, Gαs is also found on endosomes. However, the endosomal role of Gαs is still poorly understood. Our team recently demonstrated an unconventional role of Gαs protein in receptor endosomal sorting to lysosomes (Nature Communications 2014; PNAS 2017). Moreover, although the Gαs protein has been studied for over thirty years and it was believed that all the functional aspects of this protein had been elucidated, our group recently identified a new motif on this protein that allows it to interact with ubiquitin, a molecule that acts as a molecular scaffold for several signaling and intracellular transport proteins (PNAS 2017).

The main goal of this project is therefore to identify and characterize new Gαs interacting partners in order to elucidate the molecular mechanisms by which Gαs regulate endosomal sorting or active of new signaling pathways. This project could lead to the development of a novel class of therapeutic molecules to improve the effectiveness of drugs.

This research project will require the use of culture cells, advanced techniques of cell biology (confocal microscopy, superesolution), molecular biology and biochemistry including Bioluminescence Resonance Energy Transfer (BRET) assayand mass spectrometry.

Our laboratory is located in the Department of Pharmacology at the Institute of Pharmacology of Sherbrooke (IPS), in Quebec, Canada. The IPS provides an interdisciplinary research and formation environment, creating a highly stimulating research and training institute. Sherbrooke is a university town nestled in the beautiful Eastern Townships of the Province of Quebec, surrounded by mountains, rivers and lakes.

QUALIFICATION:

We are looking for a highly motivated, independent, driven and interactive candidate with strong interest in intracellular trafficking and signaling and the following qualifications:

• PhD. in a relevant discipline (biochemistry, pharmacology, cellular biology, etc). The candidate should hold a Ph.D, obtained no more than 2 years ago, or be expected to graduate with a Ph.D..
• Publications as first author in peer-reviewed journals. The most competitive candidates will be those with at least one first-author publication in the standard journals, and should be committed to eventually becoming self-funded with fellowships.
• Experience in cellular & molecular biology, biochemistry.
• Background in GPCR signaling and intracellular trafficking, will be considered a distinct advantage

TO APPLY:

Please sent a short cover letter stating your research interest and background, your CV publication list and the contact information for three references.

Applications will be accepted until the position is filled.

Job Type: Full-time

10 janvier 2019

Aucune date limite

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